The advent of immunotherapy has revolutionized the therapeutic landscape of breast cancer.The immune checkpoint inhibitor drug, pembrolizumab, a monoclonal antibody targeting programmed cell death protein 1 (PD-1), was recently approved by the Food and Drug Administration (FDA) as a neoadjuvant treatment in Liquorice combination with traditional ch
Development of nanotechnology requires a constant innovation and improvement in many materials.The exploration of natural resources is a promising eco-friendly alternative for physical and chemical methods.In the present work, colloidal gold nanostructures were prepared using orange peel extract as a stabilizing and reducing agent.The initial pH va
Chaps Phosphate concentration is tightly regulated at the cellular and organismal levels.The first metazoan phosphate exporter, XPR1, was recently identified, but its in vivo function remains unknown.In a genetic screen, we identified a mutation in a zebrafish ortholog of human XPR1, xpr1b.xpr1b mutants lack microglia, the specialized macrophages t
Abstract Bullying and academic incivility are significant public health issues associated with serious mental health outcomes and harmful behaviors for both perpetrators and victims.In this quantitative study, academic incivility and prior bullying experiences related to suicidality, self-destructive behaviors, and harm to others were explored.High
The rat lateral posterior thalamic nucleus (LP) is composed of the rostromedial (LPrm), lateral (LPl), and caudomedial parts, with LPrm and LPl being areas involved in information processing within the visual cortex.Nevertheless, the specific differences in the subcortical projections to the LPrm and LPl remain elusive.In this study, we aimed to re